df.at [ 1, 'Q' ] = 20 0 0 20 3 5 30 4 2 40 1 2 3 P Q R DataFrame df 0 0 20 20 5 30 4 2 40 1 2 3 P Q R DataFrame df at [ 1, 'Q' ] row 1 column Q 20 IN 3 OUT w3resource.com